Secondary Databases
A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. The chief … Read more
Bioinformatics
Bioinformatics is an emerging field of science that deals with the application of computers to the collection, organization, analysis, manipulation, presentation, and sharing of biological data.
- Bioinformatics is an interdisciplinary field directly involving molecular biology, genetics, computer science, mathematics, and statistics.
- The central component of bioinformatics is the study of the best ways to design and operate biologic databases.
- As a large amount of nucleotide and protein sequence data are obtained via various research techniques, along with other types of information stored in primary and secondary biological databases, scientists started to use computers to obtain and analyze biological data in their daily research with bioinformatics tools.
- To help the biologists access the databases effectively and use the analysis tools efficiently, bioinformatics has eventually become a vital part of biological education.
- Bioinformatics is an evolving discipline, and complex software programs are now being used for retrieving, sorting out, analyzing, predicting, and storing DNA and protein sequence data.
- One of the fundamental activities in bioinformatics is the sequence analysis of DNA and proteins using various programs and databases available on the world wide web.
- Large commercial enterprises such as pharmaceutical companies employ bioinformaticians to perform and maintain the large scale and complex bioinformatics needs of these industries.
- Apart from the analysis of genome sequence data, bioinformatics is now being used for a vast array of other vital tasks, including analysis of gene variation and expression, analysis, and prediction of gene and protein structure and function.
- Besides, bioinformatics has found its importance in tasks like prediction and detection of gene regulation networks and presentation and analysis of molecular pathways in order to understand gene-disease interactions.
- Bioinformatics even has clinical applications as the whole genome sequencing of an organism allows for the production of a complete list of human gene products that may provide new drugs and gene therapy for single-gene diseases may become routine.
- Bioinformatics can be used for different other fields of the biology of different groups of living beings.
Computer-Aided Drug Design (CADD)- Definition, Types, Uses, Examples, Softwares
The concept of CADD attracts attention due to its higher selectivity, efficiency, efficacy, short time duration, low toxicity, and better to fit with various pharmacokinetic parameters (Makrynitsa et al., 2018) … Read more
The Human Genome Project
The start of the human genome project in the late 1980s provided a major boost for the development of bioinformatics. The Human Genome Project (HGP) was the international, collaborative research … Read more
Genomics vs Proteomics- Definition and 10 Major Differences
Genomics and Proteomics Genomics and proteomics are closely-related fields. The main difference between genomics and proteomics is that genomics is the study of the entire set of genes in the genome of a cell whereas … Read more
Homology Modeling- Working, Steps, and Uses
Homology modeling is also known as comparative modeling predicts protein structures based on sequence homology with known structures. It is based on the principle that “if two proteins share a … Read more
Nucleotide sequences database
As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, … Read more
Protein Databases- Types and Importance
As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, … Read more
In Silico drug designing and role of bioinformatics
“In Silico” is an expression used to mean “performed on computer or via computer simulation.” In Silico drug designing is thus the identification of the drug target molecule by employing bioinformatics tools. The inventive … Read more
How to construct a Phylogenetic tree ?
A phylogenetic tree is a visual representation of the relationship between different organisms, showing the path through evolutionary time from a common ancestor to different descendants. Similarities and divergence among … Read more