Prostaglandins and Therapeutic use of Prostaglandins

Prostaglandins

Actions of Prostaglandins Prostaglandins act by binding to different G-protein coupled receptors that in return activate or inhibit adenylyl cyclase or stimulate phospholipase C. That eventually results in an enhanced formation of diacylglycerol and inositol 1,4,5-trisphosphate. Prostaglandin F2α (PGF2α), the leukotrienes, and thromboxane A2 (TXA2) activate phosphatidylinositol metabolism to perform certain functions. Thus, activation of … Read more Prostaglandins and Therapeutic use of Prostaglandins

Eicosanoids – definition, classes, functions, synthesis

Eicosanoids

Eicosanoids definition Eicosanoids are biologically active lipid derivatives of unsaturated fatty acids containing 20 carbons. Eicosanoids are locally acting bioactive hormones that act near the point of hormone synthesis and included in the class of paracrine hormones. disease. Eicosanoids are derived from arachidonic acid and related polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA). … Read more Eicosanoids – definition, classes, functions, synthesis

Pattern Recognition Receptors (PRRs) & innate immune system

Pattern Recognition Receptors (PRRs)

Pattern Recognition Receptors (PRRs) The human body has the receptors that can identify the invading microbial pathogens, these receptors are called Pattern Recognition Receptors (PRRs). PRRs are the major part of the innate immune system, recognizing the pathogens. PRRs can perform their function by recognizing conserved patterns present in microbial molecules, these molecular patterns are … Read more Pattern Recognition Receptors (PRRs) & innate immune system